October 26, 2011 at 4:52 pm | | literature

Great paper from my previous lab. And with a ridiculously hilarious acronym (a play on Hochstrasser’s PAINT): superresolution by power-dependent active intermittency and points accumulation for imaging in nanoscale topography (SPRAIPAINT). This acronym fails almost all my “GINAP” rules for initialisms, but I still love it because it joins the plethora of acronyms in the super-resolution microscopy field: PALM, FPALM, STORM, dSTORM, STED, GSDIM, PAINT, RESOLFT, SMACM, FIONA, SHREC, SHRIMP, SIM, SOFI, NALMS, … and I’m sure I’m forgetting some. This acronym shitstorm certainly deserves more. In all honesty, I think we should drop all the acronyms and just call it “pointillist super-resolution microscopy.”

The images in this paper are just beautiful! The bacteria they image are very small, basically at the diffraction limit of a conventional microscope. But they are able to image three-dimensional helices of protein filaments inside these tiny guys!

The movies are awesome:

(Click here for Movie 2)

Cool. Keep up the good work, Moerner lab.


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  1. This is REALLY INTERESTING paper. Bacteria imaging is itself difficult, but this paper is about imaging of protein inside the bacteria. I’ve never imagine this.

    You’re right about the movie, it’s awesome.

    P.S. despite this is the great research, you talk about the acronyms more than the research itself ;p

    Comment by Orlando Atkinson — October 28, 2011 #

  2. fr8 work buddies…
    tracing universe

    Comment by Aby — January 31, 2012 #

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